Aug 2026
ClinOracle: Hierarchical AI Prediction of Target Binding and Patient-Derived Functional Activity Across Diverse Therapeutic Targets
S. Abdel-Rahman, Moustafa T. Gabr
· bioRxiv · 0 citations
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Sep 2026
AI-guided discovery of a brain-penetrant LILRB4 inhibitor active in microglial and 5xFAD models of Alzheimer's disease.
In human induced pluripotent stem cell-derived microglia, compound 4 reduced SHP1/2 phosphorylation, attenuated NF-κB activation and IL-1β secretion, and restored Aβ uptake without compromising cell viability, and the compound exhibited oral bioavailability and brain penetration.
S. Abdel-Rahman, Moustafa T. Gabr
· Bioorganic chemistry (Print) · 0 citations