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Genome-Wide DNA Methylation Profiling Reveals Stage- and Severity-Associated Epigenetic Alterations in Children with Posterior Urethral Valve-Associated Chronic Kidney Disease
Background: Chronic kidney disease (CKD) is an important cause of morbidity in children, particularly in those with congenital anomalies of the kidney and urinary tract. Although epigenetic alterations have been implicated in CKD, stage-associated genome-wide DNA methylation changes remain poorly characterized in poste...