A self-crosslinkable, adhesive intestine-derived extracellular matrix hydrogel enhances organoid retention and restores intestinal barrier integrity
Disruption of the intestinal barrier impairs essential functions of the gastrointestinal tract and triggers severe inflammation. Accordingly, transplantation of intestinal organoids restores the integrity of the injured intestinal barrier by promoting regeneration. However, the dynamic mucosal microenvironment of the i...