S. Angioletti-Uberti

BAGEL-CAR: Reflections on the Bits to Binders Competition

The antigen-binding segment of chimeric antigen receptors (CARs) in CAR-T therapy has emerged as a compelling application of de novo AI protein design. In the Bits to Binders competition, our group submitted 414 BAGEL-CAR designs for CD20-directed CAR binding segments, 38.4% of which were statistically enriched in a po...