Alzheimer’s disease (AD) is the leading cause of neurodegenerative dementia and represents a significant worldwide health burden. The disease is marked by a gradual deterioration of cognitive abilities, which is closely linked to the accumulation of amyloid-β (Aβ), the development of tau-related pathology, impaired syn...
B. Kaupbayeva, A. Tsoy, A. Kassenova et al.· Astana Medical Journal· 0 citations
Tumor hypoxia is a hallmark of solid tumors that promotes aggressiveness and resistance to therapy. Within hypoxic tumors, hypoxia-inducible factor (HIF)-dependent transcriptional programs drive metabolic reprogramming, lactate accumulation, extracellular acidosis, angiogenesis, immune suppression, and invasive phenoty...
S. Askarova, Sanazar Kadyr, Aislu Yermekova et al.· Oxygen· 0 citations
AD in this Central Asian cohort was associated with a less diverse, compositionally distinct gut microbiome, with depletion of butyrate-producing Firmicutes and enrichment of sulfate-reducing taxa, alongside other taxa whose direction of association differed from prior reports.
A. Issilbayeva, S. Kozhakhmetov, A. Kushugulova et al.· International Journal of Mol...· 0 citations
Background/Objectives: Alzheimer’s disease (AD) has a substantial genetic component, yet Central Asian populations remain markedly underrepresented in genomic studies of the disease. Methods: to address this gap, we generated array-based genotype data using an immune-focused genotyping platform from a Kazakh AD case–co...
Aiym Kaiyrlykyzy, Aygerim Serikzhan, A. Kassenova et al.· Biomedicines· 0 citations
The purpose of this study is to examine the prevalence and types of violence experienced by young students, using the Childhood Trauma Questionnaire (CTQ) as a methodological framework. The research focuses on five dimensions of early adverse experiences: emotional abuse, physical abuse, sexual abuse, emotional neglect...
A. Aitysheva, G. Saparova, A. Valieva et al.· PSYCHOLOGY AND COGNITIVE SCI...· 0 citations
Chronic administration of low doses of DHQ exerted neuroprotective effects in both AD and ALS genetic models, which partially translated to reduced manifestations of these diseases.
E. Lysikova, K. Sitdikova, Aigerim Makhambetova et al.· Cells· 1 citation
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