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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Sandip Badadhe

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Review Open access Sep 2026

Proteolysis targeting chimeras for drug discovery from mechanistic basis to clinical translation

Advances establish PROTAC technology as a transformative platform in modern drug discovery while emphasizing the scientific and translational challenges that must be addressed to enable broader clinical application.

S. Badadhe, Vikas B. Gawali, Mahesh D. Bhalsing et al. · 0 citations
Aug 2026

Tetrazole–imidazole hybrid derivatives as potential EGFR tyrosine kinase inhibitors: design, synthesis and in silico evaluation with preliminary antiproliferative assessment

Combined computational and preliminary cell-based findings support compound 4i as a promising lead for further investigation of EGFR-targeted anticancer activity and biochemical EGFR kinase inhibition and target-engagement studies are required to determine the mechanism of action.

S. Badadhe, Vikas B. Gawali, C. Jangme et al. · 0 citations

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