Open access
Sep 2026
Pyridoxal-phosphate-dependent biosynthesis of aminovaleramide by AvaS in tRNA.
In eubacteria, decoding of isoleucine codon AUA requires a specialized tRNA (tRNAIle2) modified with lysidine (k2C) at the anticodon wobble position (C34), which switches decoding specificity from methionine (AUG) to isoleucine (AUA). Recently, aminovaleramide cytidine (ava2C) was discovered at the same tRNA position i...
Jing-Jing Sun, Jun-Zhou Wu, Yi-Feng Yuan et al.
· Nature Chemical Biology · 0 citations