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Review Open access Oct 2026

Gastrointestinal dysfunction and levodopa therapeutic response in Parkinson’s disease: a Brazilian cross-sectional study

Background: Levodopa therapeutic response depends on factors that determine the optimization of drug absorption and distribution. In this perspective, gastrointestinal disorders in Parkinson's disease (PD), such as constipation and gastroparesis, act as an important barrier to effective treatment, increasing the degrad...

Nara Samara Silva Felipe dos Santos, Geane Vasconcellos de Vasconcelos, Gabriel Teles de Oliveira Piñeiro et al. · 0 citations
Review Open access Oct 2026

Tavapadon as treatment for Parkinson’s disease: a systematic review, meta-analysis, and trial sequential analysis of randomized clinical trials

Background: Current Parkinson’s disease therapies are often limited by adverse events from D2/D3 receptor activation. Tavapadon, a novel selective D1/D5 partial agonist, emerges as a promising alternative for effective motor control with an improved safety profile. Objective: To perform a systematic review, meta-analys...

João Victor Teixeira Costa, S. Baran, João Pedro Fernandes Gonçalves et al. · 0 citations

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