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S. Barnett

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Open access Aug 2026

Development and validation of a LC-MS/MS method for the quantification of the E-type prostanoid receptor 4 antagonist HTL0039732 in human plasma, for a Phase I/IIa clinical trial

ABSTRACT Background HTL0039732 (HTL) is a novel E-type prostanoid receptor 4 (EP4) antagonist for the treatment of advanced solid tumors. An analytical method was developed to facilitate the analysis of patient samples as part of an ongoing Phase I/IIa clinical trial. Methods and results A LC-MS/MS method for quantifyi...

Dan Astley, S. Svetlik, S. Barnett et al. · 0 citations

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