Author

S. Bauer

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Review Open access Oct 2026

Long-term efficacy, clinical outcomes, and safety of vimseltinib in patients with tenosynovial giant cell tumor: results from the MOTION phase 3 trial

Abstract Background Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by colony-stimulating factor 1 (CSF1) gene dysregulation. Vimseltinib is an oral, switch-control tyrosine kinase inhibitor of the CSF1 receptor. In part 1 of the MOTION phase 3 trial, vimseltinib demonstrated statistically...

V. Bhadri, H. Gelderblom, S. Stacchiotti et al. · The Oncologist · 0 citations

Open access Aug 2026

Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST

A structure-based scaffold-hopping strategy to design kinase inhibitors with selectivity for mutant KIT/PDGFRA and the PDGFRA-G680R structure shows the molecular basis for targeting solvent-front mutations across oncogenic kinases.

T. Schulz, M. Beerbaum, A. Scrima et al. · Nature Communications · 0 citations