Open access
Aug 2026
PEDF/PEDF-R Signaling Regulates Retinal Phospholipid Homeostasis and Photoreceptor Survival
Pigment epithelium-derived factor (PEDF) promotes photoreceptor survival through its receptor PEDF-R, a phospholipase involved in retinal lipid metabolism. To define the in vivo function of the PEDF/PEDF-R axis, we generated mice lacking Serpinf1 (PEDF) and Pnpla2 (PEDF-R). Combined loss of Serpinf1 and Pnpla2 resulted...
Alexandra Bernardo-Colón, Susan E. Crawford, M. Agbaga et al.
· bioRxiv · 0 citations