Gaucher's disease (GD) is the most common lysosomal storage disorder caused by mutations in the GBA1 gene, resulting in deficiency of the enzyme β-glucocerebrosidase. This leads to the accumulation of glucosylceramide within macrophages, causing progressive involvement of the liver, spleen, bone marrow, and, in severe...
K. Deepthi, S. Bhargavi, G. Rani et al.· Genetics and Molecular Resea...· 0 citations
Very precise and individualized approaches developed in chemotherapy have dramatically transformed the treatment of cancer using non-selective cytotoxic agents. In the field of molecular biology, these breakthroughs enabled the development of targeted medications that selectively block the activation of oncogenic p...
S. Rahaman, Sakshi Patel, Rahul Kumar et al.· Current Drug Therapy· 0 citations
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