Author

S. Bodine

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Open access Oct 2026

Adding Tat-Beclin1 to an endurance training program promotes additive improvements in physical function in aged male mice.

Autophagy is a hallmark of aging, but it has not been exclusively targeted to attenuate aging-related physical dysfunction. Here, we combined Tat-Beclin1 and endurance training to determine its effect on physical function domains in aged male mice. Mice were randomly divided into Control (N = 5), Tat-Beclin1 (TB, 15 mg...

T. Tchen, Shakibur Rahman, T. Ghiarone et al. · Physiological Reports · 0 citations

Open access Sep 2026

ULK1 and ULK2 Restrain Skeletal Myofiber Growth by Balancing Protein Synthesis and Degradation

Background Skeletal muscle is vital for mobility and metabolic regulation, impacting independence and overall health. Increases in skeletal muscle mass and contractile function during development, and their maintenance during adulthood and aging, rely on an intricate coordination between protein synthesis and degradati...

Wangkuk Son, J. Fuqua, Matthew P. Harris et al. · bioRxiv · 0 citations

Open access Aug 2026

Temporal multi-omic analysis uncovers sex-biased molecular programs underlying skeletal muscle adaptation to endurance training.

It is indicated that sex-specific skeletal muscle exercise adaptations are particularly evident at the PTM level in rats, and future avenues for precision exercise health and medicine are identified.

Gina M. Many, Christopher A. Jin, N. Day et al. · Cell Reports · 0 citations