The Amyloid Imaging to Prevent Alzheimer’s Disease Prognostic and Natural History Study (AMYPAD-PNHS) multimodal magnetic resonance imaging (MRI) dataset provides open-access longitudinal MRI data of 2759 cognitively normal or mild cognitive impairment individuals, encompassing (micro-)structural, physiological, and functional MRI sequences from 10 European parent cohorts. Processed and raw images, and image-derived (endo-)phenotypes, are organized in Brain Imaging Data Structure (BIDS) standards and accessible upon request, to enhance generalizability and comparability between future neuroimaging studies. This dataset supports preclinical Alzheimer’s disease (AD) and aging-related research by enabling robust multimodal analyses of neurodegeneration, microvascular pathology, and structural and functional connectivity changes, facilitating advanced investigations into preclinical AD mechanisms, informing early intervention strategies and allowing reproducible and centralized neuroimaging (endo-)phenotyping.
L. Pieperhoff, M. Tranfa, Prithvi Arunachalam et al.· Scientific Data· 0 citations
Abstract INTRODUCTION Tau positron emission tomography (PET) probes Alzheimer's disease (AD) severity via regional tau spread but is not widely available. We tested whether multiregion structural magnetic resonance imaging (MRI) could approximate individual tau burden. METHODS We studied 378 Alzheimer's Disease Neuroimaging Initiative (ADNI) participants with mild cognitive impairment (MCI)‐AD or AD dementia with paired T1‐MRI and [18F]flortaucipir tau‐PET (≤6 months apart). Regional cortical thickness and volume were extracted with FreeSurfer. Principal component analysis and multivariable linear regression yielded MRI signatures of tau‐PET standardized uptake value ratio (SUVR) in Braak composite regions (I, III–IV, V–VI), a meta‐temporal region of interest (ROI), and a global neocortical meta‐ROI. Performance and high/low tau classification were evaluated by leave‐one‐out cross‐validation against published cut‐offs. RESULTS MRI signatures were significantly associated with tau‐PET burden across all regions (p < 0.001). High‐versus‐low tau discrimination varied: AUC ≈ 0.70 in Braak I, ≈0.89 in Braak V–VI, and ≈0.90 globally. Discussion Here we provide proof‐of‐concept evidence that multiregion T1‐MRI patterns can inform on tau‐PET burden in AD and may support approximate tau staging when tau‐PET is unavailable, especially in subjects with more advanced tau burden.
Martina Pulze, S. Garbarino, L. Lorenzini et al.· Alzheimer's & Dementia· 0 citations
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