Reduced Serum Klotho Levels in Disuse-Induced Skeletal Muscle Atrophy: An Experimental Study Related to Orthopedic Immobilization.
It is suggested that short-term intermittent hindlimb unloading in young adult rats is associated with reduced circulating Klotho levels and mild skeletal muscle remodeling, which may have potential implications for orthopedic conditions characterized by immobilization, including fracture treatment, casting, and postop...