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LAIAs were associated with substantially less health care utilization and fewer relapses of manic and mixed episodes, and they were not associated with increased risk of nonpsychiatric hospitalizations, notably for cardiovascular disease.
BACKGROUND Positive and negative symptoms are considered core features of psychotic disorders. However, no study has identified joint trajectories of positive and negative symptoms in early psychosis with long-term follow-up. METHOD We conducted 12-year follow-up of a randomized-controlled trial on extended early int...
Findings highlighted the importance of tracking functional changes during the initial years of illness, and identified four distinct trajectories, including persistently-good class, gradually-improved class, suboptimal-stable class, and persistently-poor class.
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