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TISON: A Web Server for Omics-driven Integrative Cancer Modeling & Simulations towards Personalized Medicine.
Next-generation sequencing (NGS) has catalyzed the generation of individualized multi-omics datasets, potentiating precise molecular insights into cancer initiation, progression, and metastasis. The subsequent data analytics have necessitated the development of computational pipelines that couple patient-specific omics...
Age-Associated NAD+ Decline and Mitochondrial Dysfunction Predispose Cells to a Reversible Tumor-Permissive Metabolic State
It is shown that mitochondrial aging creates a vulnerable metabolic environment that, combined with specific triggers, can push cells toward early tumorigenesis, offering a new framework for understanding and intervening in age-related cancer risk.