S. Çomaklı

Selenium pretreatment alleviates ANIT-induced cholestasis by preserving BSEP expression and hepatic redox homeostasis

Investigation of molecular effects of beta caryophyllene in cadmium-induced nephrotoxicity model in rats: in silico and in vivo studies.

BACKGROUND Cadmium is one of the toxic heavy metals that accumulate in the kidneys, and it can cause kidney damage by triggering oxidative stress, ER stress, inflammation, and apoptosis. β-caryophyllene (BCP) is a volatile ingredient found in various spice essential oils, known for its anti-inflammatory and strong oxyg...

Apilarnil Mitigates Copper Nanoparticle-Induced Hepatorenal Injury in Rats: Associations with Oxidative Stress, Inflammatory Markers and ER-Stress-Related Gene Expression

Background/Objectives: This study investigated the preventive effects of apilarnil (APL) against copper nanoparticle (CuNPs)-induced liver and kidney injury in rats. Methods: Thirty-five rats were randomly allocated into five groups (n = 7): Control (physiological saline), APL (400 mg/kg), CuNPs (100 mg/kg), CuNPs + AP...

Ameliorative Effects of Silymarin on Ovarian Ischemia/Reperfusion Injury via Modulation of Oxidative Stress and Inflammatory Pathways

SLY may be used as an adjuvant treatment for ovarian torsion, as it reduces oxidative stress and inflammation in OIR injury of the ovary while preserving its histological structure.