S. Condello

Beyond Mean Arterial Pressure During Cardiopulmonary Bypass: Endothelial Reactivity, Oxygen Delivery, and Organ-Specific Perfusion.

Collectively, these investigations demonstrate that CPB-associated factors such as non-pulsatile flow and the kinetics of CPB initiation, early hypotension, hemodilution, hypothermia, systemic inflammation, oxidative stress, and anesthetic-induced vasodilation impair endothelial-mediated vascular responsiveness.