Open access
Oct 2026
Development of Next-Generation ALDH1B1 Inhibitors with Enhanced Pharmacological and Functional Properties
ALDH1B1 is a mitochondrial aldehyde dehydrogenase required for the survival of stem-like colorectal and pancreatic cancer cells. Isoform-selective guanidinyl antagonists of aldehyde dehydrogenases (IGUANAs) have been developed for ALDH1B1, and here we describe structure−activity relationship (SAR) studies of three sc...
A. Tarhan, Zhi-Ping Feng, Daniel Fernández et al.
· Journal of Medicinal Chemist... · 0 citations