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Oct 2026

Oncogenic KRAS Suppresses IFNγ Signaling in Tumor Cells.

In this issue, Chen and colleagues show that MHC class II expression by pancreatic ductal adenocarcinoma (PDAC) malignant cells is a robust biomarker of both local production of IFNγ from lymphocytes and intact IFNγ signaling. RAS pathway inhibition can restore malignant cell IFNγ responsiveness in some patients, and m...

S. Dougan · 0 citations

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