Oncogenic KRAS Suppresses IFNγ Signaling in Tumor Cells.
In this issue, Chen and colleagues show that MHC class II expression by pancreatic ductal adenocarcinoma (PDAC) malignant cells is a robust biomarker of both local production of IFNγ from lymphocytes and intact IFNγ signaling. RAS pathway inhibition can restore malignant cell IFNγ responsiveness in some patients, and m...