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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

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S. E. Lehnart

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3 papers indexed here

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Review Open access Oct 2026

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine

This review provides an overview of recent advances in the development of multitarget drugs (MTDs) for cardiac diseases, with a particular focus on emerging molecular scaffolds and their pharmacological properties. We discuss the fundamental principles of cardiac polypharmacology and multitarget drug design, highlighti...

G. Y. Mitronova, V. Belov, Constanze Schmidt et al. · 0 citations
Open access Oct 2026

Wie Herzmuskelzellen Ionenkanäle dynamisch in Nanodomänen organisieren

Super-resolution microscopy is applied on Ca V 1.3 channels in stem-cell derived atrial myocytes to study cluster architectures and dynamics, finding that these channels are mobile inside membrane domains, being loosely clustered in contrast to previous models of dense channel packing.

Tobias Kohl, Roman Tsukanov, S. E. Lehnart · 0 citations
Open access Sep 2026

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric proteins. Mutations in junctophilin-2 (JPH2) are also implicated, but the underlying mechanisms remain unclear. An A405S variant in JPH2 was identified in a male adolescent patient with interventricular septal (IVS) hypertrophy. The c...

C. Quinn, S. Lahiri, A. Quick et al. · 0 citations

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