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Author

S. Fan

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Jul 2026

PLIN3 knockdown enhances T cell-mediated cytotoxicity in non-small cell lung cancer via autophagy-dependent PD-L1 degradation.

It is shown that targeting PLIN3 can induce autophagy, which promotes the degradation of PD-L1, ultimately leading to enhanced activation of T cells and an innovative approach to enhance the efficacy of immunotherapy in lung cancer.

Hanqiong Zhou, S. Fan, Min Ouyang et al. · 0 citations
Open access Aug 2026

LARS2 reprograms mitochondrial metabolism and epigenetically upregulates MHC-I to boost antitumor immunity in nasopharyngeal carcinoma

This study uncovers a novel mechanism by which the tumor suppressor LARS2 inhibits immune evasion in NPC through upregulation of MHC-I, and highlights a high-leucine diet as a promising strategy to sensitize tumors to immunotherapy.

Mei Yang, Yongzhen Mo, Dai-Xi Ren et al. · 0 citations

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