Open access
Sep 2026
Structural and Thermodynamic Analysis of BRCA1 BRCT Variants Identified in Middle Eastern Breast Cancer Cohorts.
BACKGROUND BRCA1 is a critical tumor suppressor that maintains genomic integrity through its C-terminal BRCT tandem domain, which mediates phosphoprotein interactions involved in DNA damage response signaling. Missense variants within the BRCT domain may disrupt protein stability and phosphopeptide recognition; however...
Emna Riguene, Angelos Thanassoulas, Aya Alabdulrazzak et al.
· Protein Peptide Letters · 0 citations