S. Fine-Leebhoff

Dual roles of host N-glycosylation in enteropathogenic Escherichia coli infection.

Host factors determine pathogen tropism but knowledge of host genes facilitating enteropathogenic Escherichia coli (EPEC) infection is limited. To identify host determinants required for infection by EPEC, we performed two independent genome-scale CRISPR-Cas9 screens. Both converged on host N-glycosylation as a critica...