Anaplastic ependymoma is a rare and aggressive central nervous system malignancy for which effective systemic treatment options are limited. Trastuzumab deruxtecan (T-DXd), an antibody–drug conjugate targeting human epidermal growth factor receptor 2 (HER2), has demonstrated intracranial activity in patients with HER2-...
D. Krex, I. Kerle, Arne Grey et al.· Molecular and Cellular Pedia...· 1 citation
Leiomyosarcoma is an aggressive soft tissue sarcoma that metastasizes preferentially to lung and liver. Because matched primary and metastatic specimens are rarely available, the cellular changes that accompany metastatic progression remain poorly defined. Here we combined single-nucleus RNA sequencing of archival FFPE...
Anna Kübler, L. Bergmayr, T. Knösel et al.· bioRxiv· 0 citations
Background/Objectives: Tumor-agnostic plasma ctDNA profiling is used when tumor tissue is unavailable, insufficient, or unrepresentative. We investigated analytical and biological factors associated with oncogenic variant yield. Methods: In the prospective EXMASTER study, plasma cfDNA was analyzed using a 265-gene targ...
Stephen George, L. Ranganathan, Yi-Zhen Xiang et al.· Diagnostics· 0 citations
It is demonstrated that methylation-based models can capture both diagnostic identity and clinically relevant disease stratification, supporting DNA methylation as a promising biomarker for further validation and potential clinical translation.
J. Winterstein, L. Heinlein, G. Raddatz et al.· 0 citations
It is demonstrated that targeted sequencing of minigene-derived transcripts provides a scalable approach to evaluate splice-associated SDHB variants and improve variant classification.
Anni Köhler, A. Baumann, N. Lewis et al.· npj Precision Oncology· 0 citations
TFiT (tumor-reactive features in T cells), a transcriptional classifier that identifies tumor-reactive T cells and stratifies immunotherapy, but not chemotherapy, response across independent MM and AML cohorts, supporting its specificity for T cell-mediated tumor control.
N. Kehl, T. Wagner, Simon Steiger et al.· Cancer Cell· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
