It is hypothesised that peripheral immune states responding to regional environmental triggers contribute to central neurodegeneration. Region-specific genetic selection pressures require this hypothesis to be assessed in an ancestry-specific manner. Here, we utilise genome-wide association studies and expression qua...
Aaron Z. Wagen, R. Reynolds, J. Foo et al.· Communications Biology· 0 citations
Genome-wide genetic correlations with Parkinson’s are modest, with only a significant correlation with urinary potassium-to-creatinine ratio significant, yet shared loci are identified across 9 of 15 trait pairs, providing evidence for shared genomic loci between Parkinson’s disease and kidney function.
Le Chang, Sadaf Gawhary, Lyza Maameri et al.· Nature Communications· 0 citations
Summary Alzheimer’s disease (AD) has a higher prevalence in women than men and is more frequently inherited from mothers than fathers. Yet, while neuroimaging and biomarker studies link maternal family history to stronger AD-related alterations, epidemiological studies suggest that paternal history confers comparable o...
Chloé Savignac, Frédéric St-Onge, S. Villeneuve et al.· Cell Reports Medicine· 0 citations
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