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S. Goutham

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Open access Jul 2026

CRISPR-SWITCH (silent mutations with intention to create heterozygotes): a strategy for monoallelic genome editing and generation of a Syt1-D365E mouse model of Baker–Gordon syndrome

CRISPR-SWITCH is presented, a genome engineering strategy that enables deliberate monoallelic editing by exploiting allele-specific CRISPR targeting and can enforce heterozygosity at endogenous loci and enable the generation of viable mammalian models for dominant-negative and dosage-sensitive genetic disorders.

Samantha Norris, S. Goutham, Reddy Yeddula et al. · 0 citations