Formulation design of lyotropic liquid crystalline nanoparticles governs mesophase organization, colloidal stability, and in vitro NAD+ release.
Lyotropic liquid crystalline nanoparticles (LLCNPs) are lipid-based nanosystems with ordered aqueous and lipid domains that can be exploited to accommodate challenging hydrophilic biomolecules. In this study, glyceryl monooleate (GMO)-based LLCNPs were developed for NAD⁺ loading, using Poloxamer 188 (P188) as a steric...