Open access
Jul 2026
Alterations in chromatin organization promote totipotent-like features in a DPPA2/DUX-dependent manner
It is shown that disruption of chromatin organization by degron-mediated CTCF and/or WAPL depletion promotes totipotent-like conversion through the DPPA2/DUX axis, accompanied by changes in chromatin accessibility and nucleolar integrity.
Grace Carey, Maria Vega-Sendino, Desiree Tillo et al.
· EMBO Journal · 2 citations