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Author

S. Ibrahim

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Oct 2026

Hesperidin-mediated selenium nanoparticles protect against diabetic cisplatin-induced testicular injury via modulation of Nrf2/Keap1, TLR4/NF-κB/MAPK, and PERK/CHOP Signaling.

BACKGROUND Type 2 diabetes mellitus (T2DM) and cisplatin-induced toxicity are major contributors to male reproductive dysfunction. The present study investigated the protective impacts of hesperidin (HSP), sodium selenite, and hesperidin-mediated selenium nanoparticles (HSP-SeNPs) against testicular damage induced by t...

I. Jafri, E. Fayad, Khalaf N. Alsiaam et al. · 0 citations
Open access Aug 2026

Buspirone attenuates cyclophosphamide-induced renal dysfunction in association with alterations in miR-205/EGLN2, Nrf2, and PERK/ATF4/CHOP signaling

Buspirone pretreatment mitigated CPA-induced renal dysfunction, accompanied by increased miR-205 expression, reduced EGLN2 expression, enhanced Nrf2-associated antioxidant defenses, and attenuation of ER stress, inflammation, and apoptosis, thereby preserving renal function and tissue integrity.

Ahmed M. El-Dessouki, A. Alrashidi, Mohammad I Jumaa et al. · 1 citation

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