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S. Itoh

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Open access Aug 2026

Spatiotemporal dynamics of the tumor microenvironment in hepatocellular carcinoma during combination immunotherapy

The exploratory findings suggest that ATZ/BEV may remodel the HCC microenvironment toward a state characterized by concurrent CD8+ T-cell activation and inhibitory signaling through the TIGIT–PVR/NECTIN2 axis, particularly at the tumor margin.

Hitoshi Iwasaki, S. Itoh, K. Toshida et al. · 0 citations

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