Development and Validation of a Reversed-Phase HPLC Method for Estimation of Glimepiride in Rabbit Serum and Its Application to Pharmacokinetic Studies
A reversed-phase high-performance liquid chromatography (RP-HPLC) method reported for glimepiride was modified and standardized for its estimation in rabbit serum, using pioglitazone as an internal standard (IS), to support pharmacokinetic evaluation of the drug in a rabbit model. Chromatographic separation was achieve...