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Open access Oct 2026

Unmasking tumor-induced osteomalacia: A diagnostic odyssey from ankylosing spondylitis to fibroblast growth factor 23-mediated hypophosphatemia

Background: Tumor-induced osteomalacia is a rare paraneoplastic syndrome caused by autonomous secretion of fibroblast growth factor 23 (FGF23) by occult mesenchymal tumors. Its insidious presentation frequently mimics inflammatory arthropathies, leading to misdirected therapy and severe diagnostic delay. Case summary:...

Rakesh Barshan Chaki, S. Jahan, S. Monisha et al. · 0 citations
Open access Oct 2026

An unusually severe hemorrhagic phenotype leading to prolonged diagnostic delay in PTPN11 variant Noonan syndrome

Background: Noonan syndrome is a RASopathy which carries autosomal dominant inheritance and is characterized by variable phenotypic expression involving craniofacial, cardiovascular, skeletal, hematological, and neurodevelopmental abnormalities. Bleeding manifestations are common and may result from platelet dysfunctio...

Tasnim Nusrat, Md. Latiful Bari, S. Selim et al. · 0 citations

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