S. Jha

Residue-Resolved Mapping of Heterogeneous Structural Organization during Native-to-Amyloid Transition of an Amyloidogenic Protein

Protein misfolding and aggregation in neuronal cells are key molecular events underlying several fatal neurodegenerative disorders. Effective therapeutic intervention requires residue-resolved structural information on the early aggregation intermediates that precede amyloid formation. However, these transient and he...