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Liver cancer incidences increase dramatically beyond 55 years of age, suggesting that age-associated changes contribute critically to tumor initiation. However, the mechanisms linking liver aging and cancer initiation remain incompletely defined. This study investigated the role of CD44, a marker of liver tumor-ini...
A targetable molecular axis linking the bromodomain-containing protein 2 (BRD2) complex to fibronectin-driven immune suppression in mesenchymal-like GBM niches is identified, offering a promising combinatorial therapeutic strategy.
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