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S. Karakitsios

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Open access Sep 2026

Safe and Sustainable by Design Assessment of Flame Retardant Alternatives in Household Electronic Devices: A Comparison of Phosphinate-Based and Brominated Systems.

The European Commission (EC) introduced the Safe and Sustainable by Design (SSbD) framework to support the transition toward a toxic-free environment and to foster chemical innovation through the (re)design of safer and more sustainable chemicals and materials. The present study applies the EC SSbD framework to assess...

F. Nikiforou, A. Beard, Qiang Li et al. · 0 citations
Open access Sep 2026

Mapping DEHP-induced metabolic dysregulation through multi-omics and systems biology: an adverse outcome pathway network approach

Di(2-ethylhexyl) phthalate (DEHP) is a widespread endocrine-disrupting plasticizer associated with metabolic disorders. To elucidate their mechanistic basis, we developed an Adverse Outcome Pathway Network (AOPN) informed by DEHP-induced perturbations, by integrating multi-omics data, systems biology modeling, and targ...

Elisavet Renieri, A. Karakoltzidis, N. Papaioannou et al. · 0 citations
Open access Jul 2026

Applying in silico ecotoxicity prediction to extensive datasets to support safer and more sustainable discovery chemistry.

Amide bonds are highly present in many chemical products, including pharmaceuticals and polymers. They are constituted from amines and acids, both of which are abundant in the chemical industry. Therefore, there is a need to bring these chemicals into alignment with the recent European Commission (EC) Safe and Sustaina...

F. Nikiforou, G. Selvestrel, Elisabeth I. Söderberg et al. · 0 citations

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