Susmita Kaushik

Decline of chaperone-mediated autophagy in aging impairs macrophage clearance of senescent cells.

Autophagy dysfunction and senescence are established drivers of aging, but their potential interaction remains poorly understood. Here we show that age-related decline of chaperone-mediated autophagy (CMA), a pathway for selective lysosomal protein degradation, changes senescent cell properties and impairs their immune...

Chaperone-mediated autophagy in physiological homeostasis, disease and ageing.

Regulatory T cell immunosuppressive function requires chaperone-mediated autophagy.

Regulatory T cells (Tregs) are essential for maintaining immune tolerance. We recently identified chaperone-mediated autophagy (CMA), a selective lysosomal degradation pathway, as a critical regulator of Treg function. Treg activation induces CMA, but this response is markedly diminished with aging. Mice lacking CMA sp...