Late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) reflects myocardial fibrosis and has been associated with adverse outcomes in hypertrophic cardiomyopathy (HCM). We sought to measure its incremental prognostic value beyond established clinical and phenotypic variables in a large contemporary HCM...
H. Sheashaa, S. Keen, S. Shah et al.· European Heart Journal· 0 citations
Left ventricular (LV) myocardial extracellular volume (ECV), derived from cardiac magnetic resonance (CMR) T1 mapping, reflects diffuse interstitial fibrosis and has emerged as a quantitative marker of adverse myocardial remodeling in hypertrophic cardiomyopathy (HCM). We aimed to determine the independent prognostic...
S. Shah, S. Keen, H. Sheashaa et al.· European Heart Journal· 0 citations
Obesity is frequently accompanied by low-grade systemic inflammation and increased cardiovascular risk. We evaluated whether glucagon-like peptide-1 receptor agonist (GLP-1 RA) exposure was associated with improved long-term outcomes among adults with obesity and C-reactive protein (CRP) levels of 3-10 mg/L. Using the...
Stuti Shah, M. Abusafia, Hesham Sheashaa et al.· American Journal of Cardiolo...· 0 citations
Compared with no LGE, LGE ≥10% was associated with higher risk of the composite endpoint, and higher %LGE ≥10% was associated with higher risk of the composite endpoint.
Susan K. Keen, Stuti Shah, Hesham Sheashaa et al.· Cardiovascular Research· 0 citations
Background Indexing ascending aortic dimensions to height, rather than absolute diameters, may better identify at-risk ascending aortopathy (AA) patients who could benefit from earlier surgery. Objectives This study evaluated whether height-indexed aortic dimensions improve long-term risk stratification in AA patients...
Milind Y Desai, M. Abusafia, S. Jadam et al.· JACC: Advances· 1 citation
Hypertrophic cardiomyopathy (HCM) is a prototypical inherited cardiomyopathy with well-defined sarcomeric genetic underpinnings that make it an attractive target for molecular therapy. We review recent advances in gene-based approaches for HCM, including adeno-associated virus-mediate gene replacement, allele-specific...
Susan K. Keen, Barry Greenberg, M. Desai· i Medicina· 0 citations
Indexed parameters, particularly CSAH, improve risk stratification beyond absolute diameters and highlight size-based differences in AA and provide an individualized precision imaging-based approach to surgical decision-making.
M. Abusafia, S. Jadam, Susan K. Keen et al.· JACC Cardiovascular Imaging· 1 citation
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
