Author

S. Khaw

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Open access Oct 2026

Venetoclax-Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia.

Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3-mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials. However, data on its role as a br...

Katherine S. Colman, D. Meyran, V. Malalasekera et al. · Pediatric Blood & Cancer · 0 citations

Open access Aug 2026

Closing the fusion-detection gap in single-cell RNA-seq with a scalable, probe-based workflow

Single-cell RNA-sequencing resolves cellular states in exquisite detail. Yet oncogenic gene fusions, key drivers in 16.5% of malignancies and ∼50-70% of acute lymphoblastic leukaemia (ALL) cases, remain largely invisible at this resolution. This leaves a fundamental gap in understanding cancer biology. We close it with...

Jovana Maksimovic, Victoria Streeton-Cook, Calandra V. Grima et al. · bioRxiv · 0 citations

Open access Aug 2026

High clinical utility of comprehensive multi-omic molecular profiling of rare and hard-to-diagnose pediatric tumors

The role of comprehensive genomic profiling for therapeutic decision-making is established in high-risk pediatric cancers, but its utility in rare and diagnostically challenging tumors is unclear. Here we report 123 non-high-risk patients enrolled in the Australian ZERO Childhood Cancer Program for diagnostic uncertain...

David S. Ziegler, A. Sullivan, Dong-Anh Khuong-Quang et al. · Research Square · 0 citations