Author

S. Kim

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Open access Aug 2026

Stage-dependent doxorubicin toxicity impairs C2C12 myogenesis via AMPK/AKT-FOXO signaling and is attenuated by metformin.

Doxorubicin (DOX) can compromise skeletal muscle, but whether toxicity depends on myogenic stage is unclear. C2C12 myoblasts were exposed to non‑cytotoxic DOX (0.025-0.1μg/mL) before differentiation (24h) or after 3 days of differentiation (48h), with or without metformin (Met; 0.1-2mM). Pre‑differentiation DOX markedl...

S. Kim, C. Ryu, Chawon Yun et al. · Environmental Toxicology and... · 0 citations

Open access Aug 2026

(S)‐Pyrrolo[1,2‐a]pyrazine‐3‐carboxamide Analogs as Dual Akt/JNK Modulators With Antiproliferative Effects in MDA‐MB‐468 Cells

Findings support the development of N2‐benzyl‐(S)‐1‐oxo‐1,2,3,4‐tetrahydropyrrolo[1,2‐a]pyrazine‐3‐carboxamide analogs, particularly compound B1, as selective therapeutic candidates for triple‐negative breast cancer.

Narges Hosseininasab, S. Kim, Y. Kwon et al. · ChemMedChem · 0 citations