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Author

S. Kinston

2 papers indexed here

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Open access Sep 2026

A step-wise, deterministic and fatal mouse model of myeloid neoplasm with spontaneous acquisition of patient-relevant RTK-RAS mutations.

Leukaemia arises through the stepwise transformation of healthy haematopoietic cells, yet the asymptomatic premalignant phase and its progression to overt disease remain poorly understood. To model this process, we engineered a patient-derived CEBPA mutation into Hoxb8-FL multipotent murine progenitors and transplanted...

Marija A. Zarocsinceva, Moosa Qureshi, Nicola K. Wilson et al. · 0 citations
Open access Sep 2026

Rare Hematopoietic Stem Cells resilient to infection-induced stress sense yet withstand inflammation.

Hematopoietic stem cells (HSCs) sustain lifelong hematopoiesis as their progeny differentiate into all blood cell lineages. Homeostatic HSCs are mostly quiescent and only rarely divide, however their proliferation and differentiation rates can be modulated by external factors. Acute and chronic infections from a wide r...

Christiana Georgiou, Qi Liu, Federica Bruno et al. · 0 citations

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