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Author

S. Klein

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Open access Sep 2026

Balancing lipid synthesis and oxidation promotes B cell response to vaccination during immunosuppression.

Pharmacologic immunosuppression is essential for preventing organ rejection and controlling autoimmunity, but profoundly impairs humoral immunity, increasing the risk of vaccine failure and infection. The mechanisms by which immunosuppressive therapies disrupt human B cell responses remain poorly defined. Here, we iden...

Elizabeth A. Thompson, Alexis Figueroa, Katerina Roznik et al. · 0 citations
Open access Sep 2026

Sex and age differences in antibody responses to seasonal influenza vaccination are mediated by estrogenic upregulation of NF-κB and TNF signaling in B cells

ABSTRACT Sex differences in the humoral immune responses to the seasonal quadrivalent influenza vaccine (QIV) in young adults (YA; 18–49 years old) or high-dose QIV in old adults (OA; 75+ years old) were analyzed to determine how age-related changes, including in steroids, impact sex differences in B cells. Among YAs,...

Han-sol Park, Anna Yin, Weiqiang Zhou et al. · 0 citations

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