Open access
Aug 2026
AI-enabled discovery and biochemical optimization of minibinders targeting cancer cell-surface proteins
This work presents a scalable mammalian cell-display workflow to identify AI-designed minibinders against cancer surface targets and identifies biochemical optimization beyond the binding interface as a critical requirement for translating AI-minibinders into functional applications.
B. Broske, B. McEnroe, S. C. Frechen et al.
· Nature Communications · 1 citation