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S. Kozmon

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Open access Aug 2026

Conformational switching of Trp399 regulates opening and closing of loop-1 in galactofuranosyl transferase 2 of Mycobacterium tuberculosis.

Mycobacterial cell-wall assembly depends on multiple glycosyltransferases among which the processive galactofuranosyl transferase 2 (GlfT2) executes alternating β(1 → 5) and β(1 → 6) transfers of galactofuranose (Galf) within a single catalytic site through an oxocarbenium-like transition state. Despite the well charac...

Yasir Ali, P. A. Sánchez‐Murcia, S. Kozmon · 0 citations

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