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Author

S. Kregel

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2 papers indexed here

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Oct 2026

Dose-Escalated Focal Salvage High-Dose-Rate Brachytherapy and Genomic Classifier Risk Stratification in Radiorecurrent Prostate Cancer: The F-SHARP Phase I/II Clinical Trial.

PURPOSE Prospective data on the management of intraprostatic radiorecurrence (IPR) after definitive radiotherapy (RT) and use of genomic classifiers (GC) in this setting are limited. We hypothesized that dose-escalated focal salvage high-dose-rate brachytherapy (DE-fsHDR) would be safe and effective, and that GC would...

A. Solanki, William Adams, James A. Proudfoot et al. · 0 citations
Jul 2026

Abstract B077: EMI-1725 Demonstrates Broad Antagonist Activity Against Drug-Resistant Androgen Receptor Mutations and Tumor Growth Suppression in Preclinical Models of Metastatic Castration-Resistant Prostate Cancer

In vitro and in vivo findings support the advancement of EMI-1725 as a promising therapeutic candidate for mCRPC, which showed improved biodistribution across organs and displayed less accumulation in the brain compared to enzalutamide, where off-target binding leads to risk of seizure.

S. Kregel, R. J. Kostlan, John T. Phoenix et al. · 0 citations

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