Development and Validation of Methods for Assessing the Quality of a Chemical Precursor – a Recombinant Protein Based on Ankyrin Repeats – for EGFR-Targeted Radionuclide Tumor Imaging
Introduction. Overexpression of epidermal growth factor receptor (EGFR) is characteristic of a number of malignant neoplasms, making it an important molecular target for targeted radionuclide imaging. The designed ankyrin repeat protein DARPin (HE)₃-E01 with subnanomolar affinity to EGFR is considered as a promising ch...