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S. L. Anema

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Review Open access Jul 2026

Beyond total BDNF: The proBDNF/mBDNF balance in substance use disorders

Brain-derived neurotrophic factor (BDNF) is a central regulator of synaptic plasticity, neuronal survival, and reward circuitry, all of which have been implicated in substance use disorders (SUDs). While prior research has focused on total BDNF levels, emerging evidence highlights the importance of its two major isofor...

S. L. Anema, Marcelo Melo, Sarah L Ferri et al. · 0 citations

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