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S. Ledesma-Corvi

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Open access Sep 2026

Sex and APOE Genotype Differentially Shape Microglial Transcriptomic Profiles Across the Hippocampus and Cortex

Female sex and the APOEε4 allele are top risk factors for Alzheimer’s disease (AD). Microglia play a role in the pathogenesis of AD, yet how sex and APOE genotype affect microglia remain poorly understood. Here, we characterized the transcriptomic and morphological profiles in the hippocampus and cortex of microglia fr...

S. Ledesma-Corvi, S. Blankers, Andrew J. McGovern et al. · 0 citations

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