Author

S. M. Kolk

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Open access Sep 2026

A new conditional mouse model for Cre-mediated restoration of Hprt1 expression during brain development

A central challenge in genetic neurodevelopmental disorders is determining the developmental windows, brain regions, and cell lineages that are affected by gene dysfunction, and whether the resulting pathology remains reversible. The defined genotype–phenotype relationship in Lesch–Nyhan disease (LND), a monogenic diso...

R. J. Havelaar, A. Fuss, S. Blaess et al. · bioRxiv · 0 citations

Open access Sep 2026

Tph2 deficiency shapes neurodevelopmental behavioral trajectories through interactions with the maternal environment, sex, and the gut microbiome

It is demonstrated that 5-HT depletion disrupts behavioral neurodevelopmental trajectories via interactions between genetic, environmental, and ecological factors, highlighting the importance of accounting for sex, environment, and developmental timing in translational research.

Marta C. F. Samina, Rogério C. R. Castro, Thijs Lodder et al. · Translational Psychiatry · 0 citations